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Anorexia Nervosa

Anorexia Nervosa

Overview of Anorexia Nervosa

Anorexia nervosa, commonly known as anorexia, is a serious and potentially life-threatening psychological eating disorder. It is marked by extreme self-imposed starvation, significant weight loss, a distorted view of body weight, and an intense fear of gaining weight. Essentially, it is a condition where individuals become preoccupied with their weight and food intake.


Initially, people with anorexia may start dieting to control their weight. Over time, however, their reduced food intake and restrictive eating habits turn into a psychological fixation, leading to starvation and severe weight loss. While the exact causes of anorexia nervosa are unclear, several factors are thought to contribute to its development. These factors include environmental stress, external pressures, prenatal and perinatal complications, physiological changes, neurochemical imbalances, hormonal fluctuations, and genetic predispositions.


If not addressed, anorexia nervosa can lead to severe health complications such as fatigue, low blood pressure, electrolyte imbalances, and, in extreme cases, can be fatal. Therefore, timely medical intervention and psychological support are essential for early detection and effective treatment.

Important Facts of Anorexia Nervosa

Usually seen in

Usually seen in

  • Individuals aged between 10 and 20 years.
Gender affected

Gender affected

  • Both men and women, though it is more common in women.
Body part(s) involved

Body part(s) involved

  • Stomach
  • Intestines
  • Brain
  • Kidneys
  • Heart
Prevalence

Prevalence

  • Worldwide: Less than 2% (2021)
  • India: 0.5% to 2% (2020)
Mimicking Conditions

Mimicking Conditions

  • Celiac disease
  • Achalasia
  • Body dysmorphic disorder
  • Bulimia nervosa
  • Illness anxiety disorder
Necessary health tests/imaging

Necessary health tests/imaging

  • Physical examination
  • Mental health evaluation
  • Blood tests to check vital markers
  • MRI of the brain
Treatment

Treatment

  • Psychotherapy: Family-based therapy (FBT), Cognitive Behavioral Therapy (CBT), Dialectical Behavior Therapy (DBT)
  • Medications: Cyproheptadine, Megestrol, Olanzapine
  • Nutritional therapy


Specialists to consult

Specialists to consult

  • Primary care doctor
  • Psychoanalyst
  • Nutritionist
  • Psychiatrist
  • Gastroenterologist


Symptoms Of Anorexia Nervosa

The symptoms of anorexia nervosa can vary from one person to another. The most noticeable and severe signs are significant weight loss and physical changes.

Here are some of the common symptoms:


1.Physical Symptoms

Restricting essential calorie intake over time can severely impact both the mind and body. If the negative effects of starvation are not addressed, they can lead to irreversible damage to vital organs. Common physical symptoms include:


  • Extreme fatigue
  • Dry skin
  • Sleep disturbances, such as insomnia
  • Hair thinning
  • Low blood pressure
  • Pale or discolored skin
  • Severe weight and muscle loss
  • Osteoporosis or reduced bone density
  • Brittle nails with discoloration
  • Constipation
  • Extreme thinness
  • Lanugo (growth of soft, fine hair on the body)
  • Irregular heartbeat
  • Infertility


2. Emotional and Behavioral Symptoms

Constant hunger can lead to emotional issues like anger and depression. Emotional and behavioral signs include:


  • Low self-esteem
  • Irritability
  • Dislike of food
  • Anxiety
  • Depression
  • Difficulty focusing
  • Suicidal thoughts
  • Emotional detachment or lack of interest
  • Mood fluctuations
  • Obsessive thoughts and social withdrawal
  • Excessive exercise
  • Avoidance of social situations
  • Denial of hunger
  • Withdrawal from daily activities
  • Heightened stress levels


3. Cognitive Symptoms

Anorexia nervosa can also cause cognitive changes, such as:


  • Obsession with counting calories and checking the fat content of foods
  • Preoccupation with food, recipes, or cooking, while refusing to eat or consuming minimal portions
  • Admiration of people who are thinner
  • Perception of oneself as overweight, despite being underweight
  • Distorted body image
  • Difficulty with abstract thinking or problem-solving
  • Rigid thinking and inflexibility
  • Low self-worth
  • Perfectionism and self-criticism


4. Perceptual Symptoms

This condition can distort how a person views their body and leads to negative self-judgment related to weight. Perceptual symptoms include:


  • Viewing oneself as overweight, despite being underweight (body image disturbance)
  • Increased sensitivity to cold and complaints of feeling cold, with a lowered body temperature (hypothermia) as the body attempts to conserve energy due to malnutrition
  • Altered body schema, which is an internal representation of the body based on actions and feelings


Triggering Factors Of Anorexia Nervosa

The precise causes of anorexia nervosa remain unclear, but it is generally believed to result from a combination of biological, environmental, and psychological factors. Several elements can increase a person's likelihood of developing this condition, including:


1. Psychological Factors

Anorexia nervosa is often tied to an intense fear of maintaining a "normal" weight and is closely linked to certain personality and behavioral traits. Individuals with this disorder typically strive for perfection in their physical appearance, particularly their body image. This obsession can lead them to drastically limit their food intake in an attempt to meet unrealistic expectations.

Additional psychological factors contributing to anorexia include:


  • Intense fear and anxiety
  • A history of depression or anxiety disorders
  • Traumatic or distressing childhood experiences
  • Difficulty adapting to changing situations or regulating behavior
  • Feelings of loneliness or inadequacy
  • Stressful life events, such as the loss of a loved one or an accident


2. Environmental Factors

Modern culture often glorifies extreme thinness as the ideal standard of beauty. This societal pressure, combined with the competitiveness of achieving an unrealistic body image, can lead individuals to become obsessed with restricting food intake.


3. Impact of Social Media

Social media and high-pressure environments, such as sports, modeling, and acting, can contribute to the development of anorexia nervosa. Constant exposure to media promoting unrealistic body ideals may increase dissatisfaction with one’s body and fuel the desire to adopt extreme dieting habits. Men and women are often influenced by the portrayal of slender women and muscular, V-shaped men as ideals. Research has found that magazines popular among young adults often emphasize body shape over diet, with advertisements reinforcing these ideals.

Social media platforms and websites that promote "thinspiration" or "fitspiration" can glorify anorexia by offering photos and quotes meant to inspire others to adopt these body ideals. Such content can reinforce the internalization of unhealthy body standards.


4. Biological Factors

The relationship between biological factors and anorexia is not fully understood, but certain genetic and biological traits can increase the risk of developing the disorder. A family history of anorexia, substance abuse, or other health conditions can make a person more vulnerable. Alterations in the function or structure of the hypothalamus, a brain region involved in regulating eating behaviors, may also play a role.


5. Genetic Factors

Anorexia nervosa is highly heritable, although the specific genes responsible are not well understood. Twin studies suggest a heritability rate of 28 to 58%, with first-degree relatives of individuals with anorexia being approximately 12 times more likely to develop the disorder.


A study from 2019 indicated a genetic link to mental health disorders such as schizophrenia, obsessive-compulsive disorder, anxiety, and depression. It also showed a connection to metabolic functions that affect fat storage, type 2 diabetes, and leptin levels.


One gene of interest in anorexia is associated with the estrogen-related receptor alpha (ERRalpha). This gene affects how estrogen interacts with DNA and impacts cell function. Since estrogen has a significant influence on appetite regulation, any mutations in the estrogen signaling pathway could help explain why anorexia nervosa often develops in young women following puberty.

Potential Risks for Anorexia Nervosa

Various factors can increase the likelihood of developing anorexia nervosa, ranging from psychological triggers such as relationship breakdowns and life transitions to physical conditions like type 1 diabetes. While anorexia nervosa can affect both men and women, it is more prevalent in women, who are more prone to developing negative perceptions of their bodies.


Anorexia nervosa is a multifaceted psychological disorder, and like many eating disorders, it is influenced by a combination of biological, psychological, and sociocultural factors. Below are some of the most common risk factors associated with anorexia nervosa:


  • A family history of eating disorders.
  • Diabulimia, a condition in which individuals with diabetes deliberately restrict their insulin usage in order to lose weight.
  • Extreme dieting and starvation, which can alter thought patterns and reinforce restrictive eating behaviors.
  • Psychological stress brought on by loneliness or boredom, increasing the risk of developing anorexia nervosa.
  • Age, with anorexia most frequently occurring during adolescence and puberty, although it can affect individuals at any age.


Diagnosis Of Anorexia Nervosa

If you experience symptoms like significant weight loss, an obsessive focus on body image, extreme dietary restrictions, psychological stress, or an intense fear of gaining weight, it is important to consult with a psychiatrist or nutritionist. Early detection and intervention are crucial in reducing the risks associated with anorexia nervosa.


Depending on the severity and duration of the condition, your doctor may perform physical exams and review your medical history to rule out other similar health conditions. If the symptoms are unclear, your physician may recommend various tests to aid in the diagnosis.


Physical Examination

During a physical exam for anorexia nervosa, the following aspects are typically assessed:


  • Examination of physical signs like dry skin, sunken eyes, and the development of soft hair over the body.
  • Calculation of your body mass index (BMI), which is less than 17.5 in adults or less than 85% of the expected weight for children.
  • Evaluation of vital signs, including heart rate, blood pressure, body temperature, and other malnutrition indicators.
  • Abdominal examination for stretch marks and palpation of the liver.


Psychological Evaluation

A psychological evaluation for anorexia may involve:


  • Analysis of behavior patterns such as substance abuse, self-harm, or suicidal tendencies.
  • Review of your family or medical history for any other psychological disorders.
  • Evaluation of your views on eating, appearance, and exercise.


DSM-5 Guidelines

Anorexia nervosa is classified under Feeding and Eating Disorders in the latest edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). The DSM-5 does not have a specific BMI cutoff for diagnosing anorexia nervosa.

The diagnostic criteria for anorexia nervosa include the following (all of which must be met for a diagnosis):


  • Restriction of energy intake relative to requirements, leading to significantly low body weight. (Criterion A)
  • Intense fear of gaining weight or persistent behaviors that interfere with weight gain. (Criterion B)
  • Distorted perception of one's body weight or shape or failure to recognize the risks of low body weight. (Criterion C)


The DSM-5, in its 2013 revision, removed the requirement for amenorrhea (absence of periods) as a diagnostic criterion, as it did not apply to males, women before or after menstruation, or those using birth control, and some women with anorexia still experience menstrual activity.


Levels of Severity

The DSM-5 uses BMI as an indicator of the severity of anorexia nervosa:


  • Mild: BMI greater than 17
  • Moderate: BMI between 16–16.99
  • Severe: BMI between 15–15.99
  • Extreme: BMI less than 15


Laboratory Tests

While there is no specific test to definitively diagnose anorexia, lab work can help uncover any underlying health issues linked to the condition. Common lab tests used in the diagnosis include:


  • Blood Sugar Test: Individuals with type 1 diabetes are at an increased risk of anorexia.
  • Electrolyte Level Test: Used to assess the severity and health effects of anorexia.
  • Complete Blood Count (CBC): This can help identify underlying conditions that could be contributing to anorexia.
  • Comprehensive Metabolic Profile (CMP): This test evaluates 14 parameters in the blood, providing insights into the body’s chemical balance and metabolism.
  • Urinalysis: A routine urine test can help diagnose underlying conditions related to anorexia, as well as hydration and fluid intake levels.
  • Electrocardiogram (ECG): Used to assess heart function and detect any related abnormalities.
  • Liver Function Test: These tests evaluate liver health and can be used to assess malnutrition and protein deficiencies.
  • Luteinizing Hormone (LH) Response to Gonadotropin-Releasing Hormone (GnRH): This test evaluates the pituitary gland’s response to GnRH and can help detect hypogonadism, which is commonly seen in anorexia nervosa cases.


Preventive Measures Of Anorexia Nervosa

While there are no guaranteed methods to prevent anorexia, several strategies can help reduce the likelihood of developing the condition and manage its symptoms. These include:


Early Identification of Anorexia

  • Anorexia has multiple contributing factors, and its symptoms often overlap with other psychological disorders, making it difficult to pinpoint its exact cause. However, recognizing the signs early can lead to prompt interventions, reducing the risk of complications and even death.


Adopt Healthy Eating Habits

  • The malnutrition that accompanies anorexia can severely damage the body. One effective way to prevent internal organ harm is by consuming nutrient-dense foods in smaller, more frequent meals. This is often easier to manage in the early stages of anorexia, as consuming large amounts of food can be challenging. Consulting with a dietitian or nutritionist can help create a balanced diet plan that meets your body's nutritional needs.


Avoid Alcohol Consumption

  • "Drunkorexia" refers to the dangerous behavior of replacing food intake with excessive alcohol consumption. Studies have shown a link between alcohol use and the triggering of eating disorders, including anorexia nervosa. The combination of alcohol and anorexia can result in severe, life-threatening health issues, so avoiding alcohol can help mitigate these risks.


Stop Self-Criticism

  • Individuals with anorexia often strive for perfection in every aspect of their lives. While perfectionism can be seen as a positive trait, it can also lead to unnecessary stress and mental health challenges. Learning to accept your current body, weight, and appearance can prevent the development of negative self-perceptions.


Avoid Encouraging Body Shaming

  • Allowing others to criticize your body can damage your self-esteem. Body shaming is rampant on social media and can significantly affect one's mental health. Although body shaming is prevalent in the digital age, it is important not to let negative comments affect your well-being. Practicing self-love and positive affirmations can help you maintain a healthy mindset.


Understand Anorexia and Related Eating Disorders

  • Anorexia nervosa has the highest mortality rate of any mental illness. Becoming aware of the risk factors and triggers associated with anorexia can help you avoid negative self-image issues and dissatisfaction with your body.


Seek Professional Guidance

  • If you notice any signs of anorexia or suspect you may have it, it is important to consult a doctor to better understand your condition. Early identification of the root causes of anorexia allows for quicker intervention and a greater chance of recovery.


Specialists to Consult

The signs of anorexia may not always be immediately apparent. Often, individuals with anorexia are unaware of their symptoms or may deny having a problem. If left untreated, anorexia can quickly worsen and lead to severe health complications.


Early diagnosis can significantly improve recovery outcomes. If you are concerned about your mental health or are experiencing symptoms of anorexia, it is crucial to seek medical help as soon as possible to prevent further progression and associated risks.

Specialists who can help manage anorexia include:


  • Primary care physician
  • Nutritionist
  • Psychiatrist
  • Gastroenterologist


Treatment Of Anorexia Nervosa

The goal of treating anorexia nervosa is to restore the body to a healthy weight while addressing both psychological and emotional well-being. There are various therapeutic approaches available, with treatment plans typically tailored to the individual’s age, medical conditions, and other health factors. In many cases, a combination of treatments is recommended to address issues like low self-esteem, anxiety, and other associated mental health concerns.

Here are some common approaches used in the treatment of anorexia nervosa:


Psychotherapy

Psychotherapy can assist individuals with anorexia in managing the mental health challenges associated with the disorder. It helps patients gain a better understanding of their condition and how to cope with it. Different types of psychotherapy used to treat anorexia include:


  • Family-Based Therapy (FBT): Also known as the Maudsley method, this approach involves the family in the process of helping the patient regain a healthy weight at home. The family is encouraged to work together to ensure the individual receives proper nutrition to restore a healthy weight.
  • Cognitive Behavioral Therapy (CBT): This therapy aims to improve mental well-being by focusing on changing distorted thoughts about body image and weight.
  • Dialectical Behavior Therapy (DBT): DBT focuses on identifying triggers for anorexia and developing strategies to manage them. It also helps patients improve their mental health balance.
  • Acceptance and Commitment Therapy (ACT): This therapy encourages self-motivation and personal acceptance rather than focusing solely on altering thoughts and emotions.
  • Interpersonal Therapy (IPT): IPT helps patients address relationship problems and improve their social interactions. Strengthening relationships has been shown to reduce symptoms of eating disorders.
  • Nutrition Counseling: Sessions with a nutritionist can guide patients in understanding the importance of healthy eating habits and help them restore normal eating patterns.


Medications

While there are no specific medications approved for treating anorexia nervosa itself, antidepressants or other psychiatric drugs may help address the mental health conditions associated with the disorder. Some commonly prescribed medications include:


  • Cyproheptadine: An antihistamine that helps reduce inflammation and allergic reactions, cyproheptadine also stimulates appetite by promoting the release of growth hormones.
  • Marinol: A cannabinoid that may help improve appetite and overall quality of life when used regularly.
  • Megestrol: A synthetic version of progesterone, megestrol can help stimulate appetite.
  • Olanzapine: An atypical antipsychotic that works by regulating dopamine and serotonin levels to improve mood and behavior.


Diet

Diet plays a crucial role in the treatment of anorexia nervosa and should be personalized to meet each individual’s specific needs. A balanced and varied diet is important, with a focus on high-energy foods to aid in restoring nutritional balance. The process of refeeding should begin slowly, with calorie intake gradually increasing at a manageable pace. While the use of zinc supplementation during refeeding has been suggested, its effectiveness remains uncertain.


Health Complications Of Anorexia Nervosa

Anorexia nervosa can lead to several serious medical complications, including:


  • Increased risk of cardiovascular issues such as heart valve problems, mitral valve prolapse, arrhythmias (irregular heart rhythms), or heart failure.
  • Kidney problems, including digestive disturbances.
  • Osteoporosis, where bones lose density and become more fragile.
  • Electrolyte imbalances, particularly low levels of sodium, potassium, and chloride.
  • Eye conditions, such as lagophthalmos, where the eyelids fail to fully cover the eyes during sleep, causing irritation or discomfort in the cornea.
  • Metabolic and endocrine disorders, including thyroid imbalances and infertility.
  • Amenorrhea, which refers to the absence of menstruation.
  • Gastrointestinal issues like nausea, bloating, constipation, and delayed stomach emptying.
  • Hematological disorders, including anemia (low red blood cell count) and leucopenia (low white blood cell count).
  • Neurological complications, including brain atrophy that may lead to mood changes and memory loss.


Additionally, anorexia nervosa can contribute to various psychological issues, such as:


  • Obsessive-compulsive disorder (OCD), marked by persistent, repetitive thoughts.
  • Anxiety.
  • Personality disorders.
  • Substance abuse.


Alternative Therapies For Anorexia Nervosa

Ayurvedic Remedies for Anorexia

Here are some natural and herbal approaches that may aid in managing anorexia nervosa:


Ginger (Adrak)

  • Ginger is known for its antioxidant, antibacterial, antiviral, and anti-inflammatory qualities. A small amount of lime juice and rock salt added to ginger juice can stimulate the taste buds and help neutralize excess gastric secretion.


Tamarind (Imli) and Salt

  • A mixture of tamarind and saltwater juice can stimulate the taste receptors on the tongue, which may trick the mind and encourage appetite.


Black Cardamom (Badi Elaichi)

  • Black cardamom is packed with antioxidants and has antispasmodic properties, making it helpful in relieving stress associated with eating disorders like anorexia.


Trikatu

  • Trikatu is a blend of three potent herbs: black pepper (kali mirch), ginger (adrakh), and long pepper (pippali). This combination promotes the secretion of gastric juices, aiding digestion and reducing gas. You can consume trikatu powder with water or honey.


Homemade Remedies for Anorexia Nervosa

Recovering from anorexia nervosa can be difficult, but with proper nutritional adjustments and dietary changes, it’s possible to reverse many of the negative effects caused by the condition.

Here are some guidelines to follow at home to manage anorexia nervosa:


Do’s


  • Incorporate micronutrient-rich foods such as whole grains, citrus fruits, and leafy vegetables into the diet, especially for individuals with severe anorexia.
  • Refeeding, which involves slowly reintroducing food after a period of starvation or malnutrition, should be done gradually to avoid complications.
  • Drink fresh juices to help replenish vitamin and mineral deficiencies.
  • Stay hydrated by drinking at least 2-3 liters of water per day.
  • Include fiber-rich foods like beans, lentils, broccoli, berries, and avocados in your meals.
  • Add herbs like cardamom, asafoetida, trikatu, quality-rich herbs, and ginger to your diet.


Don’ts


  • Avoid drinking aerated beverages and alcohol.
  • Limit caffeinated drinks such as coffee and tea.
  • Steer clear of refined foods like pasta, noodles, white rice, and sugary products.
  • Don’t consume food from unhygienic sources.
  • Avoid overeating processed foods, such as canned or preserved items.
  • Stay away from foods high in sodium and salt, such as pickled meats, highly salted cereals, cakes, buns, and pre-packaged soups or sauces.


Lifestyle Modifications Anorexia Nervosa

Living with anorexia nervosa can result in feelings of dissatisfaction with one's body, leading to restricted calorie intake, excessive exercise, or overuse of medications in pursuit of unrealistic fitness goals. If left untreated, the ongoing fear of weight gain can contribute to serious psychological issues such as depression, suicidal thoughts, anxiety, and social withdrawal. However, early diagnosis and timely treatment can significantly reduce the risks and complications of anorexia.


Here are some tips to help manage anorexia:


  • Recognize and understand your triggers
  • Regularly monitor your vital signs
  • Practice meditation or yoga for mental well-being
  • Stay actively engaged in activities
  • Maintain proper hydration
  • Seek professional assistance if necessary
  • Join support groups for additional help and encouragement


Frequently Asked Questions

Both anorexia nervosa and bulimia nervosa are psychological eating disorders, and people with these conditions often experience similar symptoms, such as a distorted body image. However, the primary distinction is that anorexia involves self-imposed starvation, while bulimia is characterized by episodes of binge eating followed by compensatory behaviors, such as purging, to prevent weight gain.
Anorexia can be triggered by various factors. Identifying these triggers is essential for better managing the condition. Common triggers include feelings of loneliness or boredom, stepping on the scale, obsessive thoughts about fitness, diet, and nutrition, exposure to fitness models, and pressure from social media.
While anorexia can affect both men and women, it is more prevalent among women. Young adults, particularly those going through puberty, are at a higher risk of developing anorexia due to increased external pressures.
Anorexia is a complex psychological disorder influenced by various factors. It rarely resolves on its own, and without treatment, it can lead to severe and lasting physical and mental damage. Seeking professional help is crucial for managing the condition effectively.
Starvation can have a significant impact on brain function. Research published in the International Journal of Eating Disorders shows that excessive calorie restriction may lead to shrinkage of the brain's grey matter. However, many of the brain's damages caused by anorexia can be reversed with proper treatment.
Although research is still limited, studies suggest that women may be more vulnerable to anorexia due to heightened brain activity, making them more likely to develop negative body perceptions compared to men.
Eating disorders are classified into 12 types based on their underlying causes, duration, and specific characteristics. Some of the most recognized include anorexia nervosa, bulimia nervosa, muscle dysmorphia, and binge eating disorder (BED).
Anorexia nervosa can be categorized into two types based on the presence of binging and purging behaviors: Restricting type: In this type, individuals severely limit the quantity and quality of food they consume. Binge eating/purging type: Individuals engage in binge eating followed by purging behaviors such as self-induced vomiting, the use of diuretics, enemas, or excessive exercise to eliminate calories.

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