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Dementia

Dementia

Overview of Dementia

Dementia is a progressive and chronic condition that affects the brain, leading to a decline in memory, cognitive abilities, and behavior. In advanced stages, it can interfere with the ability to perform daily tasks.


Memory loss, confusion, difficulty in problem-solving, and changes in mood are common symptoms of dementia, significantly impacting daily life. Factors such as aging, family history, cardiovascular conditions, brain injuries, and unhealthy lifestyle choices like poor diet and lack of physical activity can increase the risk of developing dementia.


There is no cure for dementia, but treatment options like medications, cognitive therapy, and lifestyle modifications can help manage symptoms. Maintaining a healthy diet, regular physical activity, and social involvement may help slow the progression and improve quality of life.

Important Facts of Dementia

Usually seen in

Usually seen in

  • Adults over 65
Gender affected

Gender affected

  • Both men and women, though more common in women
Body part(s) involved

Body part(s) involved

  • Brain
Prevalence

Prevalence

  • Worldwide: 50 million (2020)
  • India: 4.1 million (2019)
Mimicking Conditions

Mimicking Conditions

  • Depression
  • Delirium
  • Mild cognitive impairments
  • Stress
  • Senility
  • Nutritional deficiencies
Necessary health tests/imaging

Necessary health tests/imaging

  • Blood tests: Thyroid profile, Vitamin B-12, Vitamin D, CBC, ESR, Protein electrophoresis, CSF
  • Imaging studies: CT scan, MRI brain, MR angiography brain, CT angiography brain
  • Other tests: EEG, ECG, Echocardiography
Treatment

Treatment

  • Acetylcholinesterase inhibitors: Donepezil, Galantamine, Rivastigmine
  • Nerve-protecting medicine: Citicoline
  • NMDA agonists: Memantine
  • Antioxidants: Coenzyme Q10, Ginkgo biloba
  • Nootropics: Piracetam
  • COX inhibitors: Ibuprofen
  • Statins: Atorvastatin
  • SSRIs: Fluoxetine, Sertraline
  • Benzodiazepines: Lorazepam
  • Antipsychotic medications: Quetiapine
  • Supportive medications: Vitamin supplements, Antidiabetics, Antihypertensive drugs, Antibiotics, Anti-inflammatory drugs
Specialists to consult

Specialists to consult

  • General Physician
  • Neurologists
  • Neuropsychologists
  • Psychiatrists


Symptoms Of Dementia

Symptoms of dementia may include:


  • Gradual memory loss, starting from forgetfulness and increasing to an inability to recall important information such as one's name or address.
  • Difficulty with routine tasks like dressing, eating, or grooming, which were once easy to complete.
  • Trouble forming new memories and learning new information.
  • Loss of the ability to communicate effectively, with the individual struggling to recall simple words.
  • Frequent confusion and disorientation.
  • Psychological symptoms like anxiety, depression, inappropriate behavior, paranoia, and hallucinations.


Note: Dementia affects around 50 million people globally, a number expected to rise to 152 million by 2050. Alzheimer's disease is the most prevalent form, accounting for 60-70% of cases.

Triggering Factors Of Dementia

The impact of dementia on the brain varies based on its type. Most forms, apart from vascular dementia, are linked to the accumulation of specific proteins in the brain.

In Alzheimer’s disease, brain shrinkage and the buildup of protein clumps cause damage to brain cells.


Lewy body dementia and Parkinson’s disease dementia are caused by the accumulation of alpha-synuclein proteins (Lewy bodies) within brain cells.


Frontotemporal dementia is associated with genetic mutations that lead to protein buildup in the brain's frontal and temporal lobes.

Huntington’s disease is an inherited disorder caused by a defective gene, resulting in damage to brain cells.

Types Of Dementia

Alzheimer's Disease Dementia

The most common form of dementia, caused by the accumulation of harmful proteins in the brain that damage nerve cells, leading to memory loss, confusion, and impaired thinking.


Fronto-Temporal Dementia

This type occurs due to the degeneration of nerve cells in the frontal and temporal lobes of the brain, resulting in personality changes, mood swings, and abnormal behavior.


Vascular Dementia

Caused by impaired blood flow to the brain due to stroke, injury, or high blood pressure, leading to memory issues and cognitive decline.


Lewy-Body Dementia

Characterized by the presence of Lewy bodies, abnormal protein clumps in the brain, leading to stiffness, rigidity, and slow, uncoordinated movements.


Mixed Dementia

A type of dementia caused by the combination of multiple underlying causes.


Progressive Dementia

All forms of dementia worsen over time, starting with mild symptoms that gradually become more severe.


Reversible Dementia

This type of dementia is caused by treatable conditions such as vitamin deficiencies, infections, or medication side effects, and cognitive function may improve with proper treatment.

Potential Risks for Dementia

Several factors are known to increase the likelihood of developing dementia, including:


Age

The risk of dementia increases with age, particularly after the age of 65. However, it is important to note that dementia is not a natural part of aging.


Family history

If a close family member has dementia, there is a higher chance of developing it due to shared genetic factors.


Chronic health conditions

Diseases like diabetes and hypertension can elevate the risk of dementia.


Nutritional deficiencies

A lack of essential vitamins, especially the vitamin B complex, can heighten the risk of dementia.


Alcohol misuse

Heavy alcohol consumption is a significant risk factor for dementia.


Medications

Certain medications, including antidepressants like amitriptyline, anti-allergy drugs such as diphenhydramine, benzodiazepines, anticholinergics, and opioids, can increase the risk of dementia.


Diagnosis Of Dementia

To assess a person with memory loss, a doctor gathers a detailed history of the symptoms’ onset, examines family history, and conducts physical and cognitive tests to evaluate the patient’s neurological and psychological condition. Additional lab tests and imaging may be needed to pinpoint the underlying cause of dementia. These include:


Blood tests

  • Thyroid profile: Detects thyroid imbalances that may cause cognitive problems similar to dementia.
  • Vitamin B-12: Identifies B-12 deficiency, which can lead to memory issues and neurological decline.
  • Vitamin D (25-OH): Assesses deficiencies that could contribute to cognitive impairment.
  • Complete blood count (CBC): Checks for infections or anemia that may affect brain function.
  • Erythrocyte sedimentation rate: Detects inflammation that may be related to dementia-like symptoms.
  • Protein electrophoresis CSF: Identifies abnormal proteins in cerebrospinal fluid, associated with neurodegenerative diseases.


Imaging studies

  • CT scan (head): Provides clear images of the brain to detect shrinkage, strokes, or structural abnormalities linked to dementia.
  • MRI brain: Offers detailed images of brain tissue to identify atrophy, strokes, or other changes associated with dementia.
  • MR angiography brain: Examines brain blood vessels for blockages or reduced blood flow, which can contribute to vascular dementia.
  • CT angiography brain: Uses contrast dye to visualize blood vessels and detect vascular issues that may lead to dementia symptoms.


Other tests

Additional tests such as EEG (Electroencephalography), ECG (Electrocardiography), and Echocardiography may be conducted to evaluate brain and heart activity.


Preventive Measures Of Dementia

While it may not be possible to fully prevent certain types of dementia, adopting a healthy lifestyle can help reduce the risk of dementia linked to poor lifestyle choices. The key habits for prevention are:


Fuel your brain

Consume a balanced diet rich in essential vitamins and minerals to support brain function.


Stay active, stay alert

Engage in regular physical exercise for overall health, and keep your mind active with activities such as puzzles, reading, and other brain-stimulating exercises to promote cognitive health.


Manage your health

Properly manage chronic conditions like diabetes, high blood pressure, and thyroid disorders through appropriate treatment.


Prioritize rest

Maintain a consistent sleep routine to ensure deep, restorative sleep that supports brain health.


Specialists to Consult

Often, family members or loved ones notice early signs of dementia. If someone frequently forgets important tasks or shows changes in behavior, speech, and cognitive abilities, it’s crucial to have them evaluated for dementia. The following specialists can help diagnose and manage dementia:


  • General physician
  • A general physician assesses overall health, conducts initial evaluations, and refers to specialists for further diagnosis and treatment.
  • Neurologist
  • A neurologist specializes in diagnosing and managing neurological conditions, including dementia, by identifying brain-related causes.
  • Neuropsychologist
  • A neuropsychologist conducts cognitive testing to assess memory, thinking, and behavior, helping track dementia progression.
  • Psychiatrist
  • A psychiatrist addresses any psychiatric symptoms related to dementia and prescribes medications to manage mood and behavior.


Treatment Of Dementia

Dementia treatment primarily focuses on supportive care and addressing any treatable underlying causes. Treatment options include:


Medications to enhance cognitive function


  • Acetylcholinesterase inhibitors: These drugs, such as Donepezil, Galantamine, and Rivastigmine, help manage symptoms but do not halt disease progression.
  • Nerve-protecting medications: These help nourish nerve cells and protect them from damage, improving cell survival, with Citicoline being an example.
  • N-Methyl-D-Aspartate (NMDA) agonists: These reduce glutamate activity to control symptoms, such as Memantine.
  • Antioxidants: Drugs like Coenzyme Q10 and Ginkgo biloba combat free radicals, which can contribute to memory decline.
  • Nootropic drugs: These, like Piracetam, influence certain brain receptors to improve memory and mental clarity.
  • Cyclooxygenase (COX) inhibitors: Medications like Ibuprofen reduce pain and inflammation, protect neurons, and may alleviate symptoms.
  • Statins: These drugs, such as Atorvastatin, help treat dementia related to blood vessel blockages by reducing these blockages and improving symptoms.


Medications to manage anxiety and improve sleep


  • Selective serotonin reuptake inhibitors (SSRIs): Medications like Fluoxetine and Sertraline treat depression and anxiety.
  • Benzodiazepines: Drugs such as Lorazepam offer short-term relief for anxiety.
  • Antipsychotics: Medications like Quetiapine manage irritability or aggression.


Medications for reversible causes of dementia


  • Supplements: Dementia caused by nutritional deficiencies can sometimes be reversed with vitamin supplements.
  • Antidiabetic and antihypertensive drugs: Managing diabetes with oral hypoglycemics or insulin and hypertension with antihypertensives is essential if these conditions contribute to dementia.
  • Antibiotics and anti-inflammatory drugs: Infections or inflammation that cause dementia should be treated with the appropriate antibiotics and anti-inflammatory medications.


Health Complications Of Dementia

Dementia is a progressive condition that worsens over time. While current treatments can slow down the disease, they cannot halt its progression. As dementia advances, it may lead to the following complications:


  • Safety concerns: People with dementia are at higher risk of accidents, even during daily activities like walking or cooking.
  • Personal hygiene: In the later stages, individuals may have difficulty with basic hygiene tasks such as bathing, grooming, and using the restroom.
  • Nutritional difficulties: Advanced dementia can cause people to forget to eat or lose interest in food, leading to malnutrition.
  • Choking or aspiration: Difficulty swallowing food can result in choking or aspiration, potentially leading to pneumonia.


Alternative Therapies For Dementia

While alternative therapies may help manage dementia symptoms, they should not replace traditional medical treatments. Some therapies that may offer benefits include:


Exercise and Yoga

  • Gentle exercises can help enhance mood, reduce anxiety, and maintain physical activity. Activities such as home-based aerobics, dancing, light weight lifting, and yoga (including Pranayama) are effective.


Physiotherapy and Occupational Therapy

  • Physiotherapists or occupational therapists may recommend home or workplace modifications to ensure safety and prevent falls.


Massage Therapy and Aromatherapy

  • These therapies can promote relaxation and may help alleviate some symptoms of dementia.


Ayurveda

  • In Ayurveda, dementia is referred to as Smrutibuddhirhass. Treatments like Panchkarma and herbs such as Shankhpushpi, Guduchi, Brahmi, Ashwagandha, and Shatavari may help manage dementia symptoms.


Homemade Remedies for Dementia

Some home remedies might offer relief from dementia symptoms, though more research is needed to confirm their effectiveness. It’s important to note these remedies should not replace standard medical treatment. The following are some remedies to consider:


Sage:

This herb may assist in enhancing memory and cognitive function.

How to use it?: Drink it as tea or incorporate it into meals to boost memory.


Ginkgo Biloba:

Known for promoting brain circulation and mental clarity.

How to use it?: Take it in capsule or tablet form to help support cognitive health.


Lemon Balm:

A relaxing herb that can help reduce agitation and stress.

How to use it?: Drink it as tea or use the essential oil to aid relaxation.


Lavender:

Widely recognized for its ability to relieve anxiety and improve sleep quality.

How to use it?: Diffuse the oil or use it in a pillow spray to help with sleep.


St. John's Wort:

This plant may improve mood and reduce depression symptoms.

How to use it?: It can be consumed as a supplement or tea; however, consult with a doctor for proper dosage.


Curcumin:

A compound in turmeric that may help protect brain cells.

How to use it?: Add turmeric to meals or take it as a supplement for potential cognitive benefits.


Lifestyle Modifications Dementia

A dementia diagnosis can significantly impact both the individual and their caregivers. The emotional response to this diagnosis can include anxiety, depression, anger, and guilt. However, it is crucial to recognize that dementia does not necessarily mark the end of a fulfilling life. Several strategies can help individuals live well after a diagnosis:


Establish a routine

A structured daily routine can reduce confusion and anxiety. Break tasks into smaller steps for easier management.


Encourage mental stimulation

Engage in cognitive activities like puzzles, reading, or socializing to keep the brain active.


Seek emotional support

Participate in support groups or seek professional counseling to navigate emotional challenges. Stay socially connected to prevent isolation.


Monitor your condition

Work with your healthcare provider to ensure proper medication management and symptom control. Always inform your doctor of any new developments.


Tips for Caregivers

  • Encourage the individual to keep a diary or calendar for remembering important dates and events.
  • Maintain a positive and caring atmosphere at home.
  • Ensure the person with dementia has easy access to important documents, addresses, and contact numbers.
  • Due to motor issues, those with dementia may be at greater risk of falls. Ensure the living space is well-lit, clear of obstacles, and safe.
  • Never allow someone with dementia to drive or operate heavy machinery; offer assistance when needed.


Frequently Asked Questions

Many individuals with dementia, especially Alzheimer's, haven’t actually lost their memories but struggle to retrieve them. In advanced stages, complete forgetfulness may occur, and individuals may be unable to recall even basic personal details.
Foods rich in Omega-3 fatty acids, such as fish, avocados, nuts, and seeds, are vital for nervous system function. Other foods like dark chocolate, berries, and whole grains are also believed to support memory. However, the impact of these foods on dementia is still being studied.
Dementia primarily affects those aged 65 and older, though it can occasionally impact younger individuals, particularly those with conditions like traumatic brain injury, HIV, or alcoholism.

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