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Dengue

Dengue

Overview of Dengue

Dengue is a viral illness transmitted by mosquitoes. It spreads when an Aedes mosquito, infected with the dengue virus, bites a healthy individual, primarily during the daytime. The virus does not spread through touch, coughing, or other bodily fluids.


Symptoms of dengue include high fever, eye pain, skin rashes, headaches, body aches, and joint pain. In severe cases, it can cause difficulty breathing, intense abdominal pain, and bleeding. Although most cases are mild and manageable at home with hydration and medication, severe dengue (involving hemorrhage and shock) can pose a serious threat.


Preventive measures include controlling mosquito breeding sites, eliminating water stagnation, using mosquito nets, and applying repellents. People affected by dengue should rest, eat a nutritious diet, stay hydrated, and monitor their platelet count and blood pressure regularly.

Important Facts of Dengue

Usually seen in

Usually seen in

  • All age groups
Gender affected

Gender affected

  • Both men and women
Body part(s) involved

Body part(s) involved

  • Liver,
  • Lungs,
  • Brain,
  • Spleen
Prevalence

Prevalence

  • Global prevalence: 390 million cases (2019)
  • Prevalence in India: 8.8–12.9 million cases (2017)
Mimicking Conditions

Mimicking Conditions

  • Malaria,
  • Zika,
  • Chikungunya,
  • Influenza,
  • Measles
Necessary health tests/imaging

Necessary health tests/imaging

  • Dengue antigen test
  • Dengue IgM antibody test
  • Dengue IgG antibody test
  • Dengue RNA PCR test
  • Complete blood count
Treatment

Treatment

  • Paracetamol
  • Hydration therapy
  • Platelet transfusion
Specialists to consult

Specialists to consult

  • General physician,
  • Internal medicine specialist


Symptoms Of Dengue

Dengue's symptoms often overlap with other illnesses such as flu, malaria, and chikungunya. However, dengue should be suspected if high fever (around 40°C/104°F) suddenly occurs, accompanied by rashes, nausea, and body aches.

The World Health Organization (WHO) classifies dengue into three phases:


Febrile Phase

This phase typically lasts between 2 to 7 days and includes:

  • General body aches
  • Eye pain (especially with eye movement)
  • Muscle and joint pain
  • Headache
  • Loss of appetite
  • Nausea and vomiting
  • Facial flushing
  • Skin rashes
  • Respiratory symptoms (like cough, sore throat, congestion)


Critical Phase

The fever generally subsides around days 3 to 7, signaling the start of the critical phase. During this phase, there may be extreme fatigue lasting several days or even weeks. A significant drop in platelet and white blood cell counts can occur, and severe organ dysfunction or internal bleeding might develop.


Recovery Phase

After the critical phase, the patient’s condition improves over the next 48 to 72 hours. Appetite and gastrointestinal symptoms improve, though rashes might reappear.


Note: In younger children, symptoms tend to be mild, while older children and adults may experience moderate to severe symptoms, depending on the severity of the infection.


Signs of Severe Dengue

As reported by the CDC, approximately 1 in 20 individuals infected with dengue may develop severe dengue. This progression occurs around 3 to 7 days after initial symptoms appear. It’s important to note that a decrease in body temperature during this phase is a sign of deterioration, not recovery.

The warning signs of severe dengue include:


  • Intense abdominal pain
  • Full-body rash
  • Bleeding gums
  • Blood in vomit
  • Rapid heartbeat
  • Low blood pressure
  • Breathing difficulties
  • Fatigue or restlessness
  • Severe bleeding


If any of these symptoms arise, it’s crucial to seek immediate medical attention and follow your doctor’s instructions for proper care.

Triggering Factors Of Dengue

Dengue is a viral infection transmitted by the bite of an infected female Aedes Aegypti mosquito. The virus responsible for causing dengue is known as the dengue virus (DENV), a member of the Flaviviridae family. There are four distinct types of dengue virus: DENV-1, DENV-2, DENV-3, and DENV-4.


When an Aedes mosquito carrying the dengue virus bites a healthy person, the virus enters the bloodstream, leading to the infection. This type of mosquito is easily identifiable by the distinctive black and white markings on its body and typically breeds in stagnant water. It is most active during the early hours of the day. Once infected with one of the serotypes, a person gains lifelong immunity against that specific strain.

Potential Risks for Dengue

You are at a higher risk of contracting dengue if:


  • There have been several reported cases of dengue in your area.
  • Your environment has areas of stagnant water, or if you work in construction zones where mosquitoes breed more readily.
  • You travel to regions with high dengue prevalence.


Diagnosis Of Dengue

If you experience high fever, nausea, body aches, and a rash, it's advisable to undergo a blood test. A complete blood count (including platelet count) is often recommended by doctors to rule out dengue. However, this test is not specific enough to confirm the presence of the dengue virus or determine the virus type.

To accurately diagnose dengue, more specific tests are required, including:


Dengue Antigen Test

  • Also referred to as the dengue NS1 antigen test, this blood test is useful in detecting the virus early in the infection. It is most effective when conducted within the first five days of symptom onset, as the chances of false positives or negatives increase beyond this period.


Dengue Antibody IgM Test

  • This test detects IgM antibodies, which appear early in the infection. It can also differentiate between primary (first-time) and secondary (subsequent) infections with different dengue serotypes.


Dengue Antibody IgG Test

  • Used in the later stages of the illness, this test identifies IgG antibodies, which typically increase between 6 to 10 days after infection and can persist for up to 90 days or even a lifetime.


Dengue RNA PCR Test

  • This is a primary test for detecting the dengue virus in the early stages of infection. A positive result confirms the presence of the virus and helps identify the specific serotype. The test is highly sensitive (90%) and specific (95%).


Preventive Measures Of Dengue

The most effective way to prevent dengue is by reducing mosquito presence in your surroundings. To achieve this:


Eliminate Water Stagnation

  • Inspect your surroundings for any stagnant water sources, as mosquitoes breed in standing water. Always empty water containers after use, such as buckets, mugs, or bathtubs, and fix any leaks in taps to prevent water accumulation. Also, ensure water coolers and potted plants do not retain water.


Use Mosquito Nets

  • At night, use mosquito nets to protect yourself from mosquito bites. This is especially important for babies and elderly individuals who might rest during the day. Ensure windows and doors are sealed or use mesh screens to block mosquitoes from entering.


Apply Mosquito Repellents

  • Use mosquito repellents, especially for children playing outdoors. Mosquito repellent liquidators can be placed around the house. Natural alternatives like burning camphor, using lavender candles, or applying essential oils like citronella and eucalyptus can also help keep mosquitoes at bay. Keeping a tulsi plant near windows can act as a natural deterrent.


Wear Protective Clothing

  • Wear full-sleeved shirts and long pants to cover as much skin as possible. Pay special attention to ensuring children are adequately covered to minimize exposure to mosquitoes.


Specialist to Visit

While a regular fever may present with mild symptoms like sore throat, runny nose, weakness, and a high fever, dengue symptoms are more severe, including high fever, intense body aches, and a widespread rash.


If you notice any signs of dengue, it’s crucial to consult a doctor immediately. In most cases, your general physician is the appropriate first point of contact. However, depending on the situation, you may also need to consult an internal medicine specialist.

Treatment Of Dengue

There is no specific treatment for dengue, so the approach focuses on alleviating symptoms. Most people with dengue experience mild illness and can manage their condition at home by following proper dietary guidelines and taking medication as prescribed. In severe cases, where platelet levels significantly drop (known as thrombocytopenia), platelet transfusion may be required.


Rest Well

Due to the extreme fatigue and high fever associated with dengue, it is crucial to get ample rest to allow your body to recover properly.


Reduce Fever

Antipyretic medications like paracetamol are effective in reducing fever and alleviating body aches. It is important to avoid pain relievers like aspirin, as they can increase the risk of bleeding. Antibiotics are typically not needed. Sponging the body with cool water can also help bring down the fever.


Stay Hydrated

Dehydration is a common complication of dengue due to fever, vomiting, and inadequate fluid intake. To prevent dehydration, drink fluids such as coconut water, buttermilk, fruit juices, lemon water, milk, and electrolyte drinks along with water.


Monitor Your Health

The period after the fever subsides is critical. Some individuals may develop warning signs, such as vomiting multiple times a day, difficulty breathing, bleeding from the nose or gums, and blood in vomit or stool. These symptoms, which occur a day or two after the fever decreases, are seen in about 1 in 20 cases and may require hospitalization. Be vigilant and keep track of any warning signs.


Important Note: Severe dengue is a medical emergency and requires immediate attention at a hospital.


Home Remedies

Some home remedies are popularly used to manage dengue fever, as they are believed to help improve platelet count.


  • Papaya Leaves: Research suggests that papaya leaf juice may help inhibit the dengue virus's growth and boost platelet count.
  • Giloy: Known for its anti-inflammatory and fever-reducing properties, giloy juice is thought to help manage dengue fever. It is believed to increase platelet count and enhance immunity, aiding quicker recovery.
  • Kiwi: While there is no scientific evidence proving kiwi's effectiveness in raising platelet count, it is rich in Vitamin C, which supports immunity and acts as a powerful antioxidant.


Health Complications Of Dengue

In rare cases, severe dengue can lead to complications such as organ damage and internal bleeding, resulting in dengue hemorrhagic fever. This can cause a sharp drop in blood pressure, weak pulse, hypovolemia, and ultimately lead to dengue shock syndrome.

The World Health Organization (WHO) has established criteria for diagnosing dengue hemorrhagic fever, which include:


  • Low platelet count (<1 lac)
  • Fever lasting 2 to 7 days
  • Signs of internal bleeding


During the early stages of the illness, the platelet count may remain normal, but hemoglobin levels may be elevated. If hemoglobin levels exceed 14g/dL, it is important to consult a doctor even if platelet counts are normal. As the fever decreases, the platelet count typically begins to drop. Even with a declining platelet count, there is no need to panic.

Alternative Therapies For Dengue

Homemade Remedies for Dengue


Lifestyle Modifications Dengue

Frequently Asked Questions

Dengue should be considered when you experience a sudden onset of high fever, severe headache, pain behind the eyes, abdominal discomfort, body aches, rash, and vomiting. The fever typically lasts for 5-7 days.
After the fever reduces (usually between the 3rd and 7th day), it marks the start of the critical phase, where platelet counts can drop rapidly. It is crucial to monitor platelet levels and stay alert for warning signs such as bleeding, rash, abdominal pain, or vomiting.
During the first week of symptoms, the dengue PCR test and NS1 antigen are recommended. From the 3rd to the 9th day, a combination of NS1 antigen/PCR and IgM antibodies should be done. A complete blood count (CBC), including platelet count, is commonly performed, but it does not confirm the presence of the dengue virus or identify its type.
Most people with dengue can manage their condition at home without hospitalization. Ensure adequate rest, hydration (3-4 liters of fluids), and monitor platelet counts. Cold sponging and paracetamol can be used for fever management. Avoid aspirin, ibuprofen, and other painkillers, as they can worsen symptoms. Antibiotics are not required. Watch for any danger signs and follow up with your doctor regularly. Home remedies like papaya and giloy can also be tried.
Yes, it is possible. In the early stages of dengue, only white blood cells may decrease, while platelets can remain normal. Therefore, if you exhibit symptoms of dengue, it’s best to consult a doctor and get tested for the virus to be on the safe side.
Hospitalization is usually necessary if the patient is severely dehydrated, bleeding (e.g., nose or gum bleeding, or blood in vomit or stool), or showing other serious signs. A platelet count above 50,000 usually doesn’t require hospitalization, but if it drops further, contacting a doctor is essential. Platelet transfusion may be needed if the count falls below 10,000 without signs of bleeding.
Yes, it is possible to get dengue more than once. There are four different, but related, strains of the dengue virus. Having one strain does not provide immunity against the others.
Currently, Dengvaxia is not available in India due to concerns about its safety and efficacy in the Indian population. However, India is in the process of developing its own dengue vaccine, which is expected to be available in the near future.
The World Health Organization (WHO) has approved the dengue vaccine CYD-TDV (Dengvaxia) for people who have been previously infected with one of the four types of dengue virus. It is a live attenuated, recombinant tetravalent vaccine. However, it is not recommended for individuals who have never been infected with dengue, as it may cause severe complications.
Dengue is not transmitted through touch, cough, or respiratory secretions. It spreads through the bite of infected mosquitoes. The virus can be present in the blood of an infected person during the first week of the illness, so if a mosquito bites an infected person, it can spread the virus to others.

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