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Gluten Intolerance

Gluten Intolerance

Overview of Gluten Intolerance

You may have come across various gluten-free food options available in stores. Gluten is a tough-to-digest protein found in common grains like wheat, rye, and barley. It is a key ingredient in everyday foods such as rotis, parathas, bread (white and brown), cakes, cookies, biscuits, pizza, burgers, pasta, condiments like soy sauce and ketchup, ice cream, and even beer.


Gluten intolerance is a condition marked by symptoms like bloating, stomach discomfort, diarrhea, and excessive gas when gluten-containing foods are consumed.

This condition cannot be cured, but it can be managed effectively by adopting a gluten-free diet. Since grains such as wheat and barley provide vital nutrients like iron, Vitamin B, folic acid, and fiber, it's crucial to find alternative sources to fulfill these nutritional needs through diet or supplements.

Important Facts of Gluten Intolerance

Usually seen in

Usually seen in

  • All age groups
Gender affected

Gender affected

  • Both men and women
Body part(s) involved

Body part(s) involved

Prevalence

Prevalence

Mimicking Conditions

Mimicking Conditions

  • Irritable bowel syndrome (IBS)
  • Celiac disease
  • Wheat allergy
  • Dermatitis Herpetiformis
  • Lactose intolerance
Necessary health tests/imaging

Necessary health tests/imaging

To rule out other conditions:


  • Tissue transglutaminase antibody - IgA
  • Tissue transglutaminase antibody - IgG
  • Gliadin antibody IgG
  • Endomysial antibody IgG
  • Endomysial antibody IgA
  • Endomysial antibody IgM
  • Wheat allergy marker


Treatment

Treatment

  • Gluten-free diet (GFD)
  • Anti-allergic medications
  • Corticosteroids
  • Adrenaline
Specialists to consult

Specialists to consult

  • General physician
  • Gastroenterologist
  • Pediatrician
  • Nutritionist


Symptoms Of Gluten Intolerance

Symptoms typically appear within an hour after consuming gluten, though in some cases, reactions may take up to 12 hours to manifest. The common symptoms include:


Intestinal Symptoms

  • Abdominal pain (most frequent symptom)
  • Diarrhea
  • Nausea
  • Bloating


General Body Symptoms

  • Headaches
  • Joint pain
  • Muscle cramps
  • Numbness, especially in the hands and feet
  • Fatigue


Behavioral Symptoms

  • Difficulty focusing
  • Depression
  • Anxiety
  • Hyperactivity
  • Lack of balance and coordination while walking


Skin Symptoms

  • Skin redness
  • Dry, itchy patches on the skin


Triggering Factors Of Gluten Intolerance

Gluten is a protein primarily found in wheat, with rye, barley, and oats also containing it.


What triggers gluten allergy?

Normally, proteins are digested by enzymes in the stomach. However, due to gluten's high indigestible protein content, it is not fully broken down by these enzymes. The undigested gluten travels to the small intestine, where it is processed and excreted within 1-2 days.


What causes gluten intolerance?

In some individuals, gluten can pass through the intestinal barrier and activate the immune system, resulting in two possible outcomes:


  1. Allergic reaction
  2. Autoimmune reaction (gluten stays in the small intestine, triggering significant changes in the gastrointestinal tract)


This immune reaction often leads to symptoms both in the intestines and other areas of the body, primarily caused by the damage to the small intestine lining.

Types Of Gluten Intolerance

Celiac Disease

A genetic, autoimmune disorder where consuming gluten damages the small intestine. It can run in families, and if untreated, it may lead to serious health problems like thyroid issues, osteoporosis, or even intestinal cancer.


Wheat Allergy

An immediate allergic reaction after eating wheat, commonly presenting with symptoms like itching, hives, and swelling of the lips or tongue.


Non-Celiac Gluten/Wheat Sensitivity (NCGS/NCWS)

This term is used for individuals who do not have celiac disease or a wheat allergy. Those with NCGS lack the antibodies and intestinal damage found in celiac disease.


Have you heard about FODMAPs?

FODMAPs are fermentable carbohydrates that are resistant to digestion, including oligosaccharides, disaccharides, monosaccharides, and polyols. These can be found in food items like pasta, bread, onion, garlic, legumes, milk, apples, honey, processed meats, and certain sweeteners. FODMAPs have been linked to NCGS.


Note: While everyone with celiac disease is intolerant to gluten, not all individuals with gluten sensitivity will develop celiac disease.

Potential Risks for Gluten Intolerance

Diagnosis Of Gluten Intolerance

Anyone can develop gluten intolerance, but certain factors can increase the likelihood:


Family History

People with a family history of celiac disease or lactose intolerance are at a higher risk of developing gluten intolerance.


Genetic Conditions

Conditions like Down syndrome, William syndrome, and Turner syndrome can make individuals more susceptible to gluten intolerance.


Colitis

Colitis, which is the inflammation of the colon (large intestine), raises the chances of developing gluten intolerance.


Diabetes

Type 1 diabetes increases the risk of celiac disease, where the immune system mistakenly attacks the body’s own tissues.


Preventive Measures Of Gluten Intolerance

Excluding Other Digestive Conditions

Celiac disease, wheat allergy, and gluten intolerance can present similar symptoms after consuming gluten. Initially, individuals are placed on a gluten-free diet for a few weeks to observe symptom changes. If symptoms improve upon eliminating gluten, other conditions are ruled out.


Diagnosing Celiac Disease

Celiac disease is typically diagnosed by detecting specific antibodies in the blood, such as:

  • Tissue transglutaminase antibody - IgA
  • Tissue transglutaminase antibody - IgG
  • Gliadin antibody IgG
  • Endomysial antibody IgG
  • Endomysial antibody IgA
  • Endomysial antibody IgM


In certain cases, a biopsy (microscopic examination of tissue) may be needed for confirmation.


Diagnosing Wheat Allergy

  • Wheat allergy blood test: The level of IgE (an antibody) is measured as it tends to be elevated in allergic reactions.
  • Skin test: The skin is scratched with a needle containing wheat, and any reactions are monitored to check for an allergy.


Diagnosing Non-Celiac Gluten Sensitivity (NCGS)

Individuals are first given a diet containing gluten for several weeks, followed by a placebo period. A washout phase is included in which neither gluten nor placebo is consumed. Symptoms are tracked during these periods to help link gluten consumption to symptoms.


In some cases, an intestinal tissue examination may be performed for further confirmation.

Treatment Of Gluten Intolerance

While gluten intolerance cannot be fully prevented, allergic reactions can be minimized by following these lifestyle changes:


Go Gluten-Free

Gluten is naturally found in wheat, rye, and barley, with wheat-based products containing the highest levels. To avoid gluten, individuals should steer clear of the following:

  • Flour
  • Bread
  • Crackers
  • Baking mixes
  • Pasta
  • Cereal
  • Sauces
  • Processed meats
  • Beer
  • Malt vinegar


Identify Triggers

Gluten content can vary in different products, and not all gluten-containing foods cause reactions. Identify your personal triggers by eliminating all food, beverages, medications, and cosmetics containing gluten. Gradually reintroduce items to pinpoint what causes symptoms.


Be Cautious While Dining Out

Many individuals experience symptoms when eating out. It's recommended to ask for gluten-free options to ensure safety.


Check for Hidden Gluten

Some foods may contain hidden gluten, including ingredients like emulsifiers, dextrin, mono- and di-glycerides, seasonings, and caramel colors. Food can also be cross-contaminated with gluten during preparation or packaging. Look out for warning labels, especially on items such as:

  • Brown rice syrup
  • Candies
  • Wafers
  • Cold cuts
  • Hot dogs
  • Sausage
  • French fries
  • Pre-made gravies
  • Fish
  • Rice mixes
  • Sauces (e.g., soy sauce, vegetable sauce)


Specialists to Visit

Consulting a doctor is crucial for an accurate diagnosis and appropriate management.


When to See a Doctor?

Seek medical advice if you experience severe gastrointestinal symptoms alongside joint pain or headaches. If you already know you have gluten intolerance and your health hasn't improved despite eliminating gluten from your diet, it’s important to consult a specialist.


Preparation for Your Appointment


  • Track the number of servings of gluten-containing foods you consume.
  • Prepare a list of any medications and supplements you are taking.
  • Record your symptoms after consuming gluten-containing foods.
  • Document any improvements after removing these products from your diet.


Doctors Who Can Help:


  • General Physician: Helps diagnose the condition and recommends necessary interventions.
  • Gastroenterologist: Specializes in digestive issues like gluten intolerance and other related conditions such as colitis.
  • Pediatrician: Consulted for children with gluten intolerance.
  • Nutritionist: Assists in creating a gluten-free diet plan for those with gluten intolerance.


Treatment of Gluten Intolerance

While gluten intolerance cannot be cured, symptoms can be managed by adhering to a gluten-free diet. In addition, following the prevention tips and lifestyle recommendations will help reduce the frequency of allergic reactions.


In some cases, anti-allergic medications and steroids may be prescribed to control symptoms. Adrenaline may be required in cases of anaphylaxis.

Health Complications Of Gluten Intolerance

Nutritional Deficiencies:

Avoiding several gluten-containing foods can lead to malnutrition and deficiencies. It’s essential to supplement your diet with the right nutrients, but always consult with your doctor before taking any supplements.


Weight Gain:

Inflammation caused by gluten intolerance can interfere with nutrient absorption. As a result, the body may crave more food to compensate for the perceived lack of nutrients, which can lead to weight gain, even in individuals with celiac disease, despite limited food intake.

Alternative Therapies For Gluten Intolerance

Homemade Remedies for Gluten Intolerance

The following home remedies and supplements can help alleviate digestive symptoms associated with gluten intolerance. However, it's important to consult your healthcare provider before trying any of them:


  1. Ginger (Adrak): Ginger helps relieve stomach discomfort and muscle cramps that may occur after consuming gluten-containing foods. You can consume it as an extract by boiling a few pieces of ginger in water.
  2. Turmeric (Haldi): Known for its anti-inflammatory properties, turmeric can help ease stomach cramps, bloating, and nausea. You can take one teaspoon of turmeric powder directly with water or opt for turmeric supplements.
  3. Fish Oil: In cases like celiac disease, which damages the intestinal lining, fish oil can help protect the small intestine and reduce injury by coating its lining.
  4. Yogurt: Rich in beneficial bacteria, yogurt promotes digestion and supports gut health.
  5. Apple Cider Vinegar: Known to reduce bloating and other gastrointestinal symptoms related to gluten intolerance.


Lifestyle Modifications Gluten Intolerance

Gluten intolerance is a lifelong condition that may fluctuate between periods of remission and relapse. While the condition is manageable, the following lifestyle adjustments can make it easier to cope:


Know What to Eat

Finding gluten-free yet nutritious foods can be challenging. Below is a list of gluten-free options that are rich in nutrients:

  • Rice
  • Quinoa
  • Millet
  • Amaranth
  • Oats (ensure they are labeled “gluten-free,” as oats may be cross-contaminated with wheat or barley)
  • Corn
  • Buckwheat
  • Potatoes and potato flour
  • Sorghum
  • Teff

A registered dietitian can help create a personalized meal plan, possibly recommending specific supplements like fiber and calcium.


Other Important Tips


  • Learn about gluten-free options available at home.
  • Inform those around you about your condition to prevent accidental gluten exposure.
  • Remember the positive impacts of a gluten-free diet, such as maintaining a healthy weight and improving bone health.
  • Stay motivated by trying new gluten-free recipes.
  • Opt for fresh ingredients instead of processed, ready-made gluten-free products.
  • Include citrus fruits like oranges, lemons, and limes in your diet for better nutrient absorption and their antioxidant properties.


Frequently Asked Questions

The best approach is to limit foods that contain gluten, particularly gluten-rich carbs. Avoiding processed, refined, and simple carbs can help eliminate gluten and prevent the consumption of artificial ingredients and additives.
Foods made from grains, especially wheat, such as bread, pasta, and baked goods, contain the highest levels of gluten.
Celiac disease is an autoimmune disorder that causes long-term damage to the small intestine, while gluten intolerance is a sensitivity with milder symptoms.
Most individuals experience symptoms within an hour of consuming gluten. However, some people may have delayed reactions, with symptoms appearing after 12 hours or more.

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