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Rickets

Rickets

Overview of Rickets

Rickets is a childhood condition primarily marked by bone deformities such as bowed legs and an abnormally curved spine, which can cause significant pain and discomfort. It may be either hereditary (genetically passed down) or acquired due to insufficient intake of crucial nutrients.


A deficiency in nutrients like Vitamin D, calcium, and phosphorus is the main reason behind the development of rickets. Additionally, factors such as living in colder climates, having darker skin, and certain genetic traits can raise the risk.


Most commonly affecting children between 6 months and 2 years of age, rickets can be managed through Vitamin D and calcium supplementation along with increased sunlight exposure.


Preventive measures include ensuring adequate sun exposure and consuming a diet enriched with Vitamin D, calcium, and phosphorus. Treatment typically involves Vitamin D supplements and regular exposure to sunlight.

Important Facts of Rickets

Usually seen in

Usually seen in

  • Children aged 6 months to 2 years
Gender affected

Gender affected

  • Both boys and girls
Body part(s) involved

Body part(s) involved

  • Bones
  • Legs
  • Spine
  • Skeletal system
Prevalence

Prevalence

Mimicking Conditions

Mimicking Conditions

  • Osteomalacia
  • Osteogenesis imperfecta
  • Primary hypoparathyroidism
  • Lowe syndrome
  • Fanconi syndrome
  • Scurvy
Necessary health tests/imaging

Necessary health tests/imaging

  • X-rays of the bones
  • Blood investigations
  • Bone tissue biopsy
Treatment

Treatment

  • Stoss therapy
  • Multiple doses of Vitamin D
  • Calcium and phosphorus supplementation
Specialists to consult

Specialists to consult



Symptoms Of Rickets

Rickets leads to softened and weakened bones, primarily caused by long-term deficiency of Vitamin D. Watch for the following signs in children for timely intervention:

Easily Fractured Bones

  • Children with rickets often have bones that break easily due to insufficient calcium and Vitamin D, resulting in fragile skeletal structure.


Discomfort in Spine and Limbs

  • Weak and soft bones can become sore, leading to significant discomfort. Children might develop a waddling gait or fatigue quickly after walking short distances.


Dental Issues

  • Rickets can impact dental health, leading to poorly formed teeth, increased cavities, and delayed eruption of teeth.


Bone Deformities

  • Nutritional deficiencies may result in skeletal issues such as bowed legs, spinal curvature, a prominent breastbone, deformed skull, and irregular pelvis shape. Widened wrists and bowed legs are common early signs in infants and toddlers.


Delayed Growth

  • Stunted growth and short stature may be noticed due to delayed bone development.


Craniotabes

  • A condition often seen in infants older than three months, where skull bones feel soft and fontanels are broader than normal.


Chest Abnormalities

  • Includes expanded costochondral junctions and Harrison’s groove (a rib cage indentation from diaphragm pull). A “rachitic rosary,” or bead-like bumps along the ribs, may also develop.


Low Blood Calcium (Hypocalcemia)

  • Infants may show signs like convulsions and muscle cramps due to reduced calcium levels in the bloodstream.


Triggering Factors Of Rickets

Rickets is a bone disease in children that results in weak bones, muscle soreness, and structural abnormalities. Nutritional rickets, resulting from a lack of Vitamin D, calcium, or phosphorus, is the most prevalent form. Other contributing factors include inherited conditions, medication side effects, and impaired mineralization.

Here are the major types of rickets and their causes:


Calcipenic Rickets

This type, often linked to calcium deficiency and Vitamin D shortage, may also stem from absorption issues, as seen in conditions like celiac disease.


Phosphopenic Rickets

Triggered by phosphorus deficiency, this type may be due to insufficient intake, intestinal absorption problems, or excessive phosphorus loss through the kidneys.


Vitamin D-Dependent Rickets

The most widespread form, it arises from insufficient Vitamin D due to synthesis problems, receptor malfunctions, poor dietary intake, or limited sun exposure.


Genetic Factors

Some types of rickets are inherited, where mutations in specific genes hinder Vitamin D production in the body.


Familial Hypophosphatemic Rickets

This inherited form is typically X-linked dominant but can also be sporadic or autosomal recessive. It’s related to mutations in the PHEX gene, responsible for phosphate regulation.


Renal Tubular Acidosis (RTA)

A cause of refractory rickets, RTA is marked by metabolic acidosis with normal urea and creatinine levels. Symptoms include low phosphate, proteinuria, and aminoaciduria. Rickets may improve with bicarbonate and phosphate therapy.


Chronic Kidney Disease

Sometimes, rickets may be the first sign of underlying kidney problems. Elevated creatinine, phosphate, and parathormone levels are typical. Treatment includes limiting phosphate intake and supplementing with calcium and active Vitamin D.


Tumor-Induced (Oncogenic) Rickets

Certain tumors secrete substances that cause phosphate loss in urine, leading to rickets, reduced phosphorus levels, and muscle weakness.


Secondary to Other Conditions

  • McCune-Albright Syndrome: Affects bones, skin, and hormone-producing glands.
  • Epidermal Nevus Syndrome: Includes skin lesions and abnormalities in the brain, eyes, and skeleton.
  • Dent’s Disease: A chronic kidney disorder impacting proximal tubules and leading to complications such as rickets.


Potential Risks for Rickets

Several elements can increase a child’s chances of developing rickets. These include:


  • Children with darker skin are at greater risk due to the higher melanin content in their skin, which limits the body’s ability to produce Vitamin D from sunlight.
  • Residing in colder areas of India where sunlight exposure is limited.
  • Consuming a diet that lacks adequate amounts of Vitamin D, calcium, and phosphorus.
  • Infants who are exclusively breastfed, as breast milk contains only small quantities of Vitamin D.
  • Individuals who spend most of their daytime hours indoors and avoid direct sunlight.


Diagnosis Of Rickets

A pediatrician is typically the first medical professional to consult for a suspected case of rickets. The doctor will begin by conducting a physical exam, gently pressing on your child’s bones to check for tenderness or abnormalities. Special attention is given to:


  • Skull: Babies with rickets often have soft skull bones and delayed closure of fontanels (soft spots).
  • Legs: While slight bowing is normal in toddlers, severe bowing may indicate rickets.
  • Chest: Some children may develop a flat rib cage or a protruding breastbone.
  • Wrist and ankle joints: These areas may appear unusually thick or wide in affected children.


After the initial assessment, the pediatrician may suggest further tests to confirm the diagnosis, including:


  • Blood tests: These measure levels of calcium, phosphorus, parathyroid hormone, and alkaline phosphatase (ALP).
  • Urinary calcium test: Elevated calcium in the urine, especially when blood calcium is low, is a key diagnostic indicator.
  • X-rays of the bones: Used to detect any bone deformities.
  • Bone biopsy: Performed in rare cases, where a small sample of bone is removed for lab analysis.
  • DEXA scan (bone densitometry): This test assesses bone mineral density through spectral imaging.


Preventive Measures Of Rickets

To reduce the likelihood of rickets, consider the following preventive strategies:


Sunlight exposure

According to the NHS in England, exposing a child’s hands and face to the sun regularly can help prevent rickets. Limit direct sunlight exposure to under 60 minutes per day (based on skin type), and always use sunscreen if staying out longer. Avoid sun exposure between 10 AM and 4 PM when the rays are most intense.


Nutrient-rich diet

Include foods high in Vitamin D, calcium, and phosphorus in your child’s diet. Sources like oily fish, meat, mushrooms, and egg yolks are beneficial. Adding foods fortified with these nutrients can also help.

Vitamin D can also be obtained through sources like UVB exposure, cod liver oil, viosterol, and halibut-liver oil.


Vitamin D supplements

Health authorities recommend a daily intake of 10 micrograms of Vitamin D for adults, pregnant women, and children over 1 year. For infants under 1 year, a daily dose of 8.5 to 10 micrograms, or 500 ml of infant formula, is advised.


Specialist to Consult

If your child exhibits symptoms like skeletal deformities, slowed growth, bone discomfort, or muscle weakness, consult a doctor promptly.

Adults experiencing similar symptoms should also seek medical advice.

Medical professionals who can help diagnose and manage rickets include:


  • Pediatricians
  • General physicians
  • Orthopedic specialists


Treatment Of Rickets

The foundation of rickets treatment involves a nutrient-rich diet that includes adequate amounts of Vitamin D, calcium, and phosphorus. Additional treatment methods include:

Surgical intervention

  • Though most deformities due to rickets can be managed without surgery, in severe cases, operations may be needed to correct major bone abnormalities such as extreme bowing of the legs. Deformities in the chest or pelvis and significant growth delays may be irreversible.


Stoss therapy

  • This treatment involves administering a high single dose of Vitamin D, either orally or via injection, especially for infants under one month old. Oral administration is generally preferred due to faster absorption. This method is considered effective and safe for treating Vitamin D-deficient rickets.


Regular Vitamin D dosing

  • Smaller, daily doses of Vitamin D are tailored to the child’s age. Infants under 1 month typically receive 1000 IU daily, while those between 1–12 months receive 1000–5000 IU. Children over 1 year may be given 5000 IU for 2 to 3 months. A maintenance dose of 400 IU daily is then recommended.


Calcium and phosphate supplementation

  • For genetically influenced types of rickets, a pediatric endocrinologist and orthopedic specialist should oversee treatment. In cases of Vitamin D-dependent rickets, children may require large doses of calcitriol and calcium. Those diagnosed with familial hypophosphatemic rickets are usually treated with oral phosphate and Vitamin D supplements.


Health Complications Of Rickets

When rickets results from a calcium deficiency, it can trigger seizures, muscle cramps, and breathing difficulties in children. Over time, the condition may lead to more serious issues, such as:


  • Stunted growth
  • Frequent bone fractures
  • Pneumonia (fluid buildup in the lungs)
  • Dental hypoplasia (underdeveloped tooth enamel)
  • Cardiomyopathy (a condition that limits the heart’s ability to pump effectively)
  • Hydrocephalus (excess fluid accumulation in the brain cavities)
  • Seizures
  • Tooth decay
  • Skeletal abnormalities


Alternative Therapies For Rickets

Ayurveda, an ancient system of natural medicine, has long been used to treat a wide range of health conditions, including rickets. Below are a few Ayurvedic remedies that may support rickets management. Always consult a qualified Ayurvedic practitioner before use.

Pearl Ash (Moti Bhasma)

  • Give 125 mg of pearl ash with two teaspoons of honey twice a day. In more serious cases, seek advice from a certified Ayurvedic professional.


Oatstraw Baths

  • Boil dried oatstraw in 4 liters of water and use this for bathing your child twice a week.


Dandelion Tea

  • Steep dried dandelion leaves in a cup of boiling water for five minutes. Strain and offer the tea to your child.


Nettle Herb Infusion

  • Place an ounce of dried nettle in a jar, fill it with one quart of hot water, cover, and let it sit overnight. Strain and consume two cups daily.


Horsetail Tea

  • Combine one teaspoon of horsetail tea leaves with two cups of hot water and oatstraw herb. Let it steep for 5 to 7 minutes, strain, and drink after meals.


Homemade Remedies for Rickets

Medical experts emphasize the vital role of nutrition in both preventing and managing rickets. Here are some key home-care measures to follow:


  • Administer 400 IU of Vitamin D daily to children affected by Vitamin D-dependent rickets.
  • For breastfed infants, whether exclusively or partially, introduce 400 IU of Vitamin D per day until they begin consuming at least 1 liter of formula daily.
  • If your child isn’t breastfed and consumes less than a liter of formula each day, they should still receive 400 IU of Vitamin D supplementation.
  • Incorporate foods like milk, cheese, yogurt, meat, and fish into your child’s meals to help boost their intake of Vitamin D, calcium, and phosphorus.
  • If your child is lactose intolerant, consider fortified alternatives such as soy milk or orange juice, both of which are high in Vitamin D.


Lifestyle Modifications Rickets

If your child has been diagnosed with rickets, these tips can help you manage the condition effectively:


  • Administer daily Vitamin D supplements as prescribed by your healthcare provider.
  • Encourage daily sunlight exposure for 10–15 minutes, tailored to your child’s skin sensitivity.
  • Offer a balanced diet rich in dairy products, fish, and meat.
  • Engage your child in regular physical activities to help strengthen their bones.
  • Schedule visits to a qualified physiotherapist for improved mobility and pain relief.


If your child continues to experience muscle cramps or discomfort, consult your doctor for further evaluation. A physiotherapist can also assist in managing symptoms and improving movement.


In certain cases, doctors may suggest using braces to promote straight bone growth and support limb development. Braces might also be used after surgery. While there’s limited scientific evidence supporting bracing as a treatment for rickets, follow your doctor’s recommendations regarding proper usage and consistency.

Although rickets can cause considerable discomfort, the condition is treatable when managed with proper care, a nutritious diet, appropriate therapy, and regular outdoor activity. Caregivers play a crucial role in supporting the child’s recovery and overall well-being.

Frequently Asked Questions

Rickets responds well to early treatment. With proper sun exposure and nutrient-rich food, noticeable improvement can be seen within three months. Studies show full recovery is possible within six months with timely intervention.
Yes, rickets can sometimes be misidentified as osteogenesis imperfecta (a genetic bone disorder) or osteomalacia (Vitamin D deficiency in adults), as they share similar symptoms related to bone weakness.
Adults don’t get rickets, but they can suffer from osteomalacia, a condition involving bone softening and weakening due to a severe Vitamin D deficiency. This condition can lead to frequent bone fractures.
Children should get 10–30 minutes of sun exposure daily in tropical regions, while in colder areas, they may need up to 1–2 hours. Limit sun exposure to mornings or evenings to reduce UV intensity. Children with darker skin might require additional Vitamin D supplementation, as they may not produce enough from sunlight alone. Also, avoid sun exposure beyond 60 minutes daily to reduce the risk of skin damage.
A pediatrician is the most appropriate first point of contact. If one is unavailable, you may visit a general physician. For more complex cases, an orthopedic specialist may be consulted.
Yes. Fortified orange juice has been shown to boost Vitamin D levels. Studies have found that consuming fortified juice can improve Vitamin D status, making it a helpful dietary addition.
Children who cannot consume dairy can still get Vitamin D through soy milk, fortified orange juice, fish, meat, and mushrooms. Supplements are also an effective alternative.

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