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Glivec 400mg Tablet

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Novartis India Ltd

Salt Composition

Imatinib mesylate (400mg)

Overview Glivec 400mg Tablet

Imatinib mesylate 400mg tablets are indicated for various cancers. Primary uses include treating hematological malignancies (chronic myeloid leukemia and acute lymphoblastic leukemia) and gastrointestinal stromal tumors. Its mechanism involves targeting specific proteins crucial to cancer cell proliferation and metastasis. This medication also addresses dermatofibrosarcoma protuberans and aggressive systemic mastocytosis. Administer with food, consistently at the same time daily for optimal efficacy. Continue treatment as directed by your physician; duration is individualized. Incorrect usage or overdose can cause severe adverse reactions. Therapeutic benefits may take weeks or months to manifest; do not discontinue without consulting your doctor. Common side effects include swelling, nausea, vomiting, muscle spasms, musculoskeletal discomfort, diarrhea, skin rash, tiredness, and stomach pain. Report sudden, significant weight increase. Regular blood count and liver function monitoring may be advised. Avoid activities requiring alertness if dizziness or blurred vision occur. Inform your healthcare provider of all other medications, as interactions are possible. This medication is contraindicated during pregnancy and breastfeeding; reliable contraception is essential for both partners throughout the treatment period.

Uses of Glivec 400mg Tablet

Cancer Therapy

Major Benefits of Glivec 400mg Tablet:

Consume this medication precisely as your physician directs, adhering to the prescribed dosage and treatment period. Ingest the tablet whole; avoid chewing, crushing, or fracturing it. The 400mg Glivec tablet should be administered with food.

Common Side effects of Glivec 400mg Tablet:

  • Edema (swelling)
  • Nausea
  • Vomiting
  • Muscle cramp
  • Musculoskeletal (bone, muscle or joint) pain
  • Diarrhea
  • Rash
  • Fatigue
  • Abdominal pain
  • Bleeding
  • Breathing problems
  • Cough
  • Weight gain
  • Dry eye
  • Dizziness
  • Hemorrhage

How to use Glivec 400mg Tablet:

Consume this medication precisely as your physician directs, adhering to both the prescribed dosage and treatment length. Ingest the tablet whole; avoid chewing, crushing, or fracturing it. The 400mg Glivec tablet should be taken with a meal.

How Glivec 400mg Tablet works:

Imatinib mesylate 400mg tablets are a cancer treatment. They target the bcr-abl tyrosine kinase, a protein enzyme driving uncontrolled cancer cell growth. The drug's mechanism involves blocking this enzyme's activity, thus curtailing cell replication and triggering programmed cell death in bcr-abl-positive cancerous cells. This action helps to control or retard the disease's progression.

SAFETY ADVICE

AlcoholAlcoholCONSULT YOUR DOCTOR

Alcohol consumption alongside Glivec 400mg Tablets may pose unknown risks. Seek medical advice before combining them.

PregnancyPregnancyCONSULT YOUR DOCTOR

Imatinib mesylate 400mg tablets should not be taken during pregnancy due to confirmed risks to the fetus. In exceptional, life-threatening circumstances, a physician might prescribe it if the potential benefits outweigh the risks. Always seek medical advice.

Breast feedingBreast feedingCONSULT YOUR DOCTOR

Breastfeeding while taking Glivec 400mg Tablets is likely unsafe. Limited evidence indicates potential drug transfer to breast milk, posing a risk to the infant. Mothers using this medication should discontinue breastfeeding during treatment and for 15 days following its cessation.

DrivingDrivingUNSAFE

Taking a 400mg Glivec tablet may impair your driving ability due to potential adverse effects.

KidneyKidneyCAUTION

Imatinib 400mg tablets require careful administration in individuals with impaired renal function. Dosage modification may be necessary. Physician consultation is recommended.

LiverLiverCAUTION

Imatinib 400mg tablets require careful administration in patients exhibiting severe hepatic impairment. Dosage modification for imatinib 400mg tablets may be necessary. Physician consultation is advised.

What if you forget to take Glivec 400mg Tablet :

Omit any missed Glivec 400mg Tablet dose and resume your usual medication regimen. Avoid taking a double dose.

Facts to Know About Glivec 400mg Tablet

LabelValue
Chemical Type Benzanilide Derivative
Developing Habits No.
Treatment Category Cancer Medications
Action Class TKIs (Tyrosine Kinase Inhibitors)

FAQs on Glivec 400mg Tablet

For best results, take with food and water to minimize stomach and esophageal irritation. If swallowing the tablet is difficult, dissolve it in 50ml of water or apple juice (for 100mg tablets) or 200ml (for 400mg tablets). Stir until dissolved and drink immediately.
Taking Glivec 400mg tablets may cause dizziness, lightheadedness, or drowsiness. Avoid driving or operating machinery until you understand how this medication affects you.
Follow your doctor's instructions precisely and attend all scheduled appointments while taking Glivec 400mg tablets. Regular monitoring, including blood, urine, and weight checks, is necessary to detect and manage potential side effects. Use contraception to prevent pregnancy during treatment, and immediately report any pregnancy to your doctor. Always inform your doctor if you begin taking any other medication while on Glivec 400mg tablets.
This medication can significantly increase your skin's sensitivity to sunlight, potentially leading to rash, itching, redness, or severe sunburn. Always wear protective clothing and a sunscreen with SPF 15 or higher when outdoors. Report any burning sensation to your doctor immediately.
Several medications, such as paracetamol, cyclosporin, dexamethasone, warfarin, antivirals (for AIDS), and drugs for bacterial infections, high cholesterol, high blood pressure, heart conditions, mental health disorders, and depression, interact negatively with Glivec 400mg. Avoid self-medicating while on Glivec; always consult your doctor before taking any other medication, informing them of your Glivec 400mg therapy.
Glivec 400mg tablets have shown effectiveness in numerous chronic myeloid leukemia (CML) cases, often improving survival rates. Your doctor is best equipped to determine if this medication is right for you, considering your individual condition, blood work, treatment response, and overall health.
Glivec 400mg Tablet
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